Complement activation is a crucial pathogenic factor in catastrophic antiphospholipid syndrome
نویسندگان
چکیده
The data for this study were provided by the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis (BSRBR-RA). The BSRBR-RA is funded by a grant from the BSR. The BSR currently receives funding from AbbVie, Pfizer, Roche and UCB and in the past from Swedish Orphan Biovitrium and Merck. This income finances a wholly separate contract between the BSR and the University of Manchester to host the BSRBR-RA. All decisions concerning analyses, interpretation and publication are made autonomously from any industrial contribution.
منابع مشابه
Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy loss and thrombosis in the presence of antiphospholipid (aPL) Ab's. Currently, therapy for pregnant women with APS is focused on preventing thrombosis, but anticoagulation is only partially successful in averting miscarriage. We hypothesized that complement activation is a central mechanism of pregnancy loss in APS and tested thi...
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Antiphospholipid syndrome (APS) is characterized by thrombosis (arterial, venous, small vessel) and/or pregnancy morbidity occurring in patients with persistently positive antiphospholipid antibodies (aPL). Catastrophic APS is the most severe form of the disease, characterized by multiple organ thromboses occurring in a short period and commonly associated with thrombotic microangiopathy (TMA)....
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